乳腺癌组织中IL-6与PRL表达及其临床意义
Expression of IL-6 and PRL in breast cancer tissue and its clinical significance
目的 探讨白介素-6（interleukin-6，IL-6）和催乳素（prolactin，PRL）在乳腺浸润性导管癌（breast invasive ductal carcinoma，BIDC）组织中的表达及临床意义。 方法 采用免疫组化法对63例乳腺癌及其癌旁组织、17例乳腺纤维瘤中IL-6和PRL的表达进行检测，结合临床病理参数及无事件生存（event free survival，EFS）进行统计学分析。 结果 浸润性导管癌组织中IL-6和PRL阳性率均高于癌旁组织及乳腺纤维瘤组织（P均＜0.05）；癌旁组织中IL-6和PRL的表达高于瘤旁组织（P均＜0.05）；IL-6、PRL的表达均与肿瘤大小、TNM分期相关（P均＜0.05）；IL-6与PRL表达呈显著正相关（rs=0.842，P＜0.05）。EFS显示，IL-6、PRL高表达组患者EFS均低于低表达组患者（分别为IL-6，Log- rank= 5.186，P= 0.023；PRL， Log- rank= 5.743，P= 0.017）。单因素Cox风险模型显示，淋巴结转移、TNM分期高、IL-6阳性表达、PRL阳性表达均对患者的EFS有影响。 结论 检测乳腺癌中PRL和IL-6的表达有利于其预后诊断；通过缓解病人的紧张、促进情绪调节、改善睡眠质量等因素可在一定程度上降低乳腺癌的发生、进展及不良预后的风险。
Objective To investigate the expression of interleukin-6 (IL-6) and prolactin (PRL) in breast invasive ductal carcinoma (BIDC) and its clinical significance. Method Immunohistochemistry was used to detect the expression of IL-6 and PRL in 63 cases of breast cancer and its paraneoplastic tissues and 17 cases of breast fibroadenoma. The clinical pathological parameters and event-free survival were analyzed statistically. Results The positive rates of IL-6 and PRL in infiltrating ductal carcinoma were higher than those in adjacent tissues and fibroids (P<0.05). The expressions of IL-6 and PRL in the adjacent tissues were higher than those in paratumor tissues (P<0.05). The expression of IL-6 and PRL were correlated with tumor size and TNM stage (P<0.05). There was a significant positive correlation between IL-6 and PRL expression (rs= 0.842, P<0.05). Event-free survival showed that the event-free survival of patients with high expression of IL-6 and PRL was lower than that of patients with low expression (IL-6, Log- rank= 5.186, P= 0.023; PRL, Log- rank= 5.743, respectively. P= 0.017). The univariate Cox risk model showed that lymph node metastasis, high TNM stage, positive IL-6 expression, and positive PRL expression all had influence on the event-free survival of patients. Conclusion The detection of PRL and IL-6 expression in breast cancer is beneficial to its prognosis diagnosis; Reducing the patient's stress, promoting emotional regulation, improving sleep quality and other factors can, to some extent, reduce the risk of breast cancer, progression and poor prognosis.
乳腺肿瘤 / IL-6 / PRL / 免疫组织化学 / 预后
/ Breast tumor / IL-6 / Prolactin / Immunohistochemistry / Prognosis
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