目的　研究云南白族地区乳腺癌EphA2和EphrinAl的表达及其与临床病理因素的关系。 方法　用免疫组织化学(IHC)检测乳腺癌组织中EphA2、EphrinAl的表达，比较各自表达情况与临床病理因素的关系及二者间的相关性。   结果　EphA2、EphrinAl主要表达于肿瘤细胞和血管内皮细胞的胞浆和胞膜，呈棕黄色或棕褐色。150 例乳腺癌组织中，EphA2、EphrinAl阳性表达分别为123例、129例，阳性率分别为82%、86%。二者的阳性率与患者年龄无相关性(P>0.05)，而与病理类型、肿瘤大小、淋巴结转移、临床分期和组织学分级有相关性(P<0.05)。浸润性导管癌EphA2和EphrinAl阳性率较导管内癌的高；肿瘤较大组、淋巴结转移组、临床分期较晚者、组织学分级较高组EphA2和EphrinAl的阳性率分别高于肿瘤较小组、无淋巴结转移组、临床分期较早者、组织学分级较低组EphA2和EphrinAl的阳性率。EphA2和EphrinAl阳性染色共同定位于大致相同的肿瘤区域和血管内皮细胞，二者的阳性率有相关性(P<0.05)。   结论　EphA2、EphrinAl在乳腺癌高表达，并与其发生发展、侵袭转移及恶性程度有关，有望成为乳腺癌预后评估标志物，为早期诊断和靶向治疗提供新思路。

Objective　To investigatethe expression of EphA2 and EphrinAl in the breast carcinoma tissue fromYunnan Dali Bai, Han and other minority women and its relation to clinicopathological parameters. Methods　The expression of EphA2 and EphrinAl in the breast carcinoma tissue was detected by the immunohistochemistry (IHC) method and was compared with theclinicopathological parameters and with each other, respectively.　Results　EphA2 and EphrinA1 were mainly expressed in cytoplasm and membrane of tumor cells and of vascular endothelial cells, showing a tan or brown color. Out of 150 cases of breast cancer tissues, the positive expression of EphA2 and EphrinA1 appeared in 123 and129 cases, and the positive rates of them are 82% and 86%, respectively. The positive expression rates of EphA2 and EphrinAlhave no significant correlation with the patient age (P>0.05), but are correlated statistically with the pathological type, tumor size, lymph node metastasis, clinical stage and histological grade (P<0.05). The positive rates of EphA2 and EphrinAl in the invasive ductal carcinoma are higher than that in the intraductal carcinoma; and the positive rates of EphA2 and EphrinAl in the group with large size, lymph node metastasis, late clinical stage and high histological grade was higher than that in the group with a small size, negative lymph node metastasis, early clinical stage and a low histological grade, respectively. The positive staining of EphA2 and EphrinAliscolocalized in roughly the same tumor areas and vascular endothelial cells.Their distributions were fundamentally unanimous and their positive expression rates were positively correlated (P<0.05).　Conclusion　Over expression of EphA2 andEphrinA1 can be observed in breast carcinoma, which isconcerned with carcinogenesis, development, invasion, metastases and malignant transformation, suggesting that EphA2 and EphrinA1 may be associated with tumour prognosis and could be used as new markers for prognosis evaluation. Our research has laid a theoretical foundation for early diagnosis and targeted therapy of breast carcinoma.