阿尔茨海默病患者松果体MRI研究

邓玲; 钱学华; 郭轶; 徐玉玉; 吕发金

doi:10.13418/j.issn.1001-165x.2016.04.005

中国临床解剖学杂志 ›› 2016, Vol. 34 ›› Issue (4) : 378-382. DOI: 10.13418/j.issn.1001-165x.2016.04.005

断层影像解剖

阿尔茨海默病患者松果体MRI研究

邓玲¹，　钱学华¹，　郭轶²，　徐玉玉¹，　吕发金²

作者信息 +

The pineal gland MRI study in Alzheimer's patients

DENG Ling¹，QIAN Xue-hua¹，GUO yi²，XU Yu-yu¹，Lü Fa-jin²

Author information +

文章历史 +

摘要

目的　观察阿尔茨海默病（Alzheimer’s disease，AD)发病进程中松果体的MRI形态学改变。方法　依据AD发病进程，分别采集NC组24例、MCI组18例、轻度AD组16例、中-重度AD组20例受试者大脑MRI扫描图像，测量松果体矢径、横径、高、体积，并分析组间各测量值变化趋势。结果　松果体标化高MCI期、轻度AD期较NC组增大（P＜0.05），中-重度AD期标化高较MCI期、轻度AD缩小（P＜0.05）；松果体标化矢径、标化横径、标化体积MCI期、轻度AD、中-重度AD与NC组比无明显变化（P＞0.05），但中-重度AD较MCI期组缩小（P＜0.05）。结论　在AD发病进程中松果体高先增大再萎缩，松果体高对MCI期、轻度AD患者的诊断有较大价值。

Abstract

Objective　To observe morphological changes of pineal gland in the process of Alzheimer' s disease (AD) by MRI. 　Methods　According to the process of AD, brain MRI images of 24 cases, 18 cases, 16 cases and 20 cases from the normal control group, MCI group, mild AD group and moderate-severe AD group, respectively. Length, width, height and volume of the pineal gland had been measured, the change trend of the measurement between each group was then analyzed.　Results　The standardized height of pineal gland had an increase in the MCI and mild AD compared with NC group （P＜0.05）and had a reduction in the moderate-severe AD compared with the MCI and mild AD（P＜0.05）; The standardized length, width and volume of pineal gland had no significant change in the MCI, mild AD and moderate-severe AD compared with NC group（P＞0.05），but had a reduction in the moderate-severe AD compared with MCI（P＜0.05）.　Conclusion　The height of pineal gland has a growth tendency at the incipient stage of the process of AD, and then will shrink. Measurement the height of pineal gland by MRI was helpful in the diagnosis of MCI and mild AD patients.

导出引用

邓玲,钱学华,郭轶,徐玉玉,吕发金. 阿尔茨海默病患者松果体MRI研究[J]. 中国临床解剖学杂志. 2016, 34(4): 378-382 https://doi.org/10.13418/j.issn.1001-165x.2016.04.005

DENG Ling，QIAN Xue-hua，GUO yi，XU Yu-yu，Lü Fa-jin. The pineal gland MRI study in Alzheimer's patients[J]. Chinese Journal of Clinical Anatomy. 2016, 34(4): 378-382 https://doi.org/10.13418/j.issn.1001-165x.2016.04.005

参考文献

[1] Jack CR,Albert MS,Knopman DS, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnosticguidelines for Alzheimer's disease [J]. Alzheimers Dement, 2011, 7(3): 257-262.
[2] 李亚迪，何慧瑾，冯晓源，等. 基于体素的轻度阿尔茨海默病全脑灰质MRI成像分析[J]. 中国医学计算机成像杂志， 2009，15(2)：97-101.
[3] 李传明，王健，桂莉, 等. MRI定量观察阿尔茨海默病患者全脑皮质表面积[J]. 中国医学影像技术，2011，27(12)：2440-2443.
[4] Sun X, Salat D, Upchurch K,et al. Destruction of white matter integrity in patients with mild cognitive impairment and Alzheimer disease[J]. JInvestig Med, 2014, 62(7):927-933.
[5] 曹志宏，王冬青，吴立伟，等.阿尔茨海默病侧脑室变化的磁共振研究[J]. 临床放射学杂志，2013，32(1)：29-32.
[6] 俱西驰，屈秋民，张明，等. 磁共振测量嗅球容积在阿尔茨海默病早期诊断中的价值[J]. 南京医科大学学报：自然科学版，2011，9(9)：1337-1340.
[7] Bumb JM, Brockmann MA, Groden C, et al. Microstructural analysis of pineal volume using trueFISP imaging[J]. World J Radiol, 2013, 5(4):166-172.
[8] 白桂芹，刘尚清，张华，等. 基于人脑纹状体与海马结构的断层影像学研究[J]. 中国临床解剖学杂志，2015，33(4)：393-402.
[9] 邓玲，钱学华，周庭永，等. 正常成人松果体MRI研究[J]. 中国临床解剖学杂志，2015，33(4)：403-407.
[10]Bumb JM, Schilling C, Enning F, et al. Pineal gland volume in primary insomnia and healthy controls: a magnetic resonance imaging study[J]. J Sleep Res, 2014, 23(3): 276-282.
[11]Bersani G, Garavini A, Iannitelli A, et al. Reduced pineal volume in male patients with schizophrenia: no relationship to clinical features of the illness[J]. Neurosci Lett, 2002, 329(2): 246-248.
[12]Han Y, Wang J, Zhao Z, et al. Frequency-dependent changes in the amplitude of low-frequency fluctuations in amnestic mild cognitive impairment: a resting-state fMRI study[J]. Neuroimage, 2011, 55(1):287-295.
[13] Wang Z, Yan C, Zhao C, et al. Spatial patterns of intrinsic brain activity in mild cognitive impairment and Alzheimer's disease: a resting-state functional MRI study [J]. Hum Brain Mapp, 2011, 32(10): 1720-1740.
[14]Rosales-Corral S, Tan DX, Reiter RJ, et al. Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid- β peptide in rat brain: a comparative, in vivo study versus vitamin C and E[J]. J Pineal Res, 2003, 35(2):80-84.
[15]Feng Z, Chang Y, Cheng Y, et al. Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease[J]. J Pineal Res, 2004, 37(2): 129-136.
[16]Hardeland R, Cardinali DP, Brown GM, et al. Melatonin and brain inflammaging[J]. Prog Neurobiol, 2015, 127(2): 46-63.
[17]Mahlberg R, Walther S, Kalus P,et al.Pineal calcification in Alzheimer's disease:An in vivo study using computed tomography[J]. Neurobiol Aging, 2008, 29(2):203-209
[18]Wu YH, Feenstra MG, Zhou JN, et al. Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: alterations in preclinical and clinical stages[J]. J Clin Endocrinol Metab, 2003, 88(12): 5898-5906.