The experimental study on proliferation and migration pathway of the neural stem cells in the rats following intracerebral hemorrhage

  • SHANG Hua-Jun ,
  • FAN Guang-Bi ,
  • ZHENG Yu-Jie ,
  • DENG Chi ,
  • GAO Xiao-Jing ,
  • YANG Chao-Xian
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  • 1. Department of Anatomy,Luzhou Medical College, Luzhou 646000, China;  2. Department of Neurobiology, Luzhou Medical College, Luzhou 646000, China

Received date: 2014-05-05

  Online published: 2015-04-21

Abstract

Objective    To investigate proliferation and migration pathways of the neural stem cells in the rats following intracerebral hemorrhage (ICH).    Methods    The 75 SD rats were randomly divided into the ICH group, sham group and normal group the ICH group received  injection of autologous blood to establish the ICH model. The bromodeoxyuridine (BrdU) was used to mark neural stem cells. Proliferation, migration and distribution of neural stem cells were observed by immunohistochemical staining.   Results BrdU-positive cells located in the ependymal epithelium of subventricular zone increased significantly in the ICH group compared with the control group and normal group( P<0.05), and migrated along corpus callosum, and finally settled in the hemorrhagic focus and the surrounding area.    Conclusion   Neural stem cells in the rats following ICH can proliferate and migrate to the hemorrhagic focus and surrounding area along corpus callosum, and participate in repairing the nerve function of hemorrhagic brain injury.

Cite this article

SHANG Hua-Jun , FAN Guang-Bi , ZHENG Yu-Jie , DENG Chi , GAO Xiao-Jing , YANG Chao-Xian . The experimental study on proliferation and migration pathway of the neural stem cells in the rats following intracerebral hemorrhage[J]. Chinese Journal of Clinical Anatomy, 2015 , 33(2) : 189 -192 . DOI: 10.13418/j.issn.1001-165x.2015

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