Chinese Journal of Clinical Anatomy >
Effect of dimebon on NMDA-activated current in mice medium spiny neuron
Received date: 2014-08-21
Online published: 2015-02-12
Objective Dimebon is an antihistamine compound which has been proposed to treat neurodegenerative disorders, but the mechanism remain elusive. To explore Dimebon effection on Alzheimer's disease and Huntington's disease. Method Membrane currents were measured by using whole cell patch clamp techniques. the influence ofdifferent concentration of Dimebon on NMDA -activated currents in primary Medium Spiny Striatal Neuronal cultures (MSN) from wild type (WT) mice were studied. Results 1~50 μmol/L Dimebon inhibited NMDA activated currents, but 0.1~0.5μmol/L increased NMDA activated currents. Conclusion Dimebon has dual function on NMDA receptors.
Key words： Dimebon; ; Medium spiny striatal neurons; NMDA receptor
HU Xiao-Li , LI Qin , SONG Lou , Ilya Bezprozvanny . Effect of dimebon on NMDA-activated current in mice medium spiny neuron [J]. Chinese Journal of Clinical Anatomy, 2015 , 33(1) : 89 -92 . DOI: 10.13418/j.issn.1001-165x.2015
［1］Bachurin S, Bukatina E, Lermontova N, et al. Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer［J］. Ann N Y Acad Sci, 2001,939:425-435.
［2］ Bezprozvanny I, Hayden MR. Deranged neuronal calcium signaling and Huntington disease［J］. Biochem Biophys Res Commun ,2004, 322(4):1310-1317.
［3］ Tang TS, Slow E, Lupu V, et al. Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease
[J].Proc Natl Acad Sci USA, 2005, 102(7):2602-2607.
［4］ Wu J, Li Q, Bezprozvanny I, et al. Evaluation of Dimebon in cellular model of Huntington's disease［J］.Mol Neurodegener, 2008，3:15.
［5］ Grigorev VV, Dranyi OA, Bachurin SO. Comparative study of action mechanisms of dimebon and memantine on AMPAand NMDA-subtypes glutamate receptors in rat cerebral neurons［J］. Bull Exp Biol Med ,2003, 136(5):474-477.
［6］ Lermontova NN, Redkozubov AE, Shevtsova EF,et al. Dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block L-type Ca(2+) channels［J］.Bull Exp Biol Med ,2001, 132(5):1079-1083.
［7］ Bachurin SO, Shevtsova EP, Kireeva EG, et al. Mitochondria as a target for neurotoxins and neuroprotective agents［J］. Ann N Y Acad Sci,2003, 993:334-344.
［8］ Doody RS, Gavrilova SI, Sano M, et al. Effect of dimebon on cognition,activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease:a randomised, double-blind,placebo-controlled study
[J]. Lancet,2008,372(9634):207-215.
/
| 〈 |
|
〉 |
