Research progress on vertebral cartilage development-related molecules in the pathogenesis of congenital scoliosis

doi:10.13418/j.issn.1001-165x.2025.1.18

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Chinese Journal of Clinical Anatomy ›› 2025, Vol. 43 ›› Issue (1) : 112-115. DOI: 10.13418/j.issn.1001-165x.2025.1.18

Research progress on vertebral cartilage development-related molecules in the pathogenesis of congenital scoliosis

Zhao Xingchen¹, Ye Yongyu¹, Dai Jingxing², Yu Tao¹, Cheng Xing¹, Yin Dong¹, Ouyang Jun², Chang Yunbing¹, Chen Chong¹*

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Abstract

The vertebral body originates from the body segments and is an important part of spine. Its developmental abnormalities are related to various diseases such as congenital scoliosis (CS). During human embryonic development, mesenchymal cells derived from somites differentiate into vertebral cartilage cells and then ossify to form vertebral bodies. During this process, vertebral cartilage development is coordinated and regulated by a variety of molecular signals. However, there is no comprehensive review on the relationship between the development process of vertebral cartilage and the pathogenic factors of CS. Therefore, we summarized the molecular mechanisms related to the development of vertebral cartilage and CS, and elucidated the molecular regulation behind the pathogenic factors of CS, in order to find clinical better methods to treat CS provide theoretical basis and research direction.

Key words

Vertebral Body; / / Cartilage Development; / / Congenital Scoliosis; / / Signal Molecule / Causative Factor

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Zhao Xingchen, Ye Yongyu, Dai Jingxing, Yu Tao, Cheng Xing, Yin Dong, Ouyang Jun, Chang Yunbing, Chen Chong. Research progress on vertebral cartilage development-related molecules in the pathogenesis of congenital scoliosis[J]. Chinese Journal of Clinical Anatomy. 2025, 43(1): 112-115 https://doi.org/10.13418/j.issn.1001-165x.2025.1.18

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