Analyses on stereology of mitochondrion of neurons that surround intracerebral hemorrhage in rats and the neuroprotective effect of astragalus injection for intracerebral hemorrhage
WANG De-Ke, ZHANG Hai-Yu, LIU Hai-Xiang, QIN Yi
Chinese Journal of Clinical Anatomy ›› 2013, Vol. 31 ›› Issue (6) : 692-695.
Analyses on stereology of mitochondrion of neurons that surround intracerebral hemorrhage in rats and the neuroprotective effect of astragalus injection for intracerebral hemorrhage
Objective To study the protective effect of astragalus to the ultrastructure of apoptotic neurons which surround the intracerebral hemorrhage (ICH). Methods ICH model was established by injecting collagenase Ⅶ into the brain of rats. Method of Narrow-alley Test was applied to study behavioral index. The ultrastructure of neurons around the intracerebral hemorrhage in rats was observed by transmission electron microscope and a stereology analysis was performed on the mitochondria. Results mpared with model group, stereology analysis of nerve mitochondria, volume density, numerical density, specific surface and specific membrane of the astragalus treatment group increased notably(P＜0.05). Conclusion Astragalus could protect neurons located near the hemorrhage brain area and abate the neuronal apoptosis with this efficacy better at an early stage following hemorrhage.
Intracerebral hemorrhage / Astragalus injection / Stereology / Mitochondrion / Rat
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