Effects of ischemic acute kidney injury on ultrastructure of rat lung
LIU Yu-Ling, GUO Min, SHAO You-Zhi, BAO Cui-Fen
Chinese Journal of Clinical Anatomy ›› 2012, Vol. 30 ›› Issue (5) : 556-559.
Effects of ischemic acute kidney injury on ultrastructure of rat lung
Objective To observe the ultrastructural changes of damaged lung induced by ischemic acute kidney injury (IAKI) in rats. Methods Transmission Electron Microscopy and morphometric analysis were used in this study. Results Both type I and II alveolar cells undergoing necrosis could be seen in the lungs damaged by IAKI. Disappeared osmiophilic multilamellar bodies of damaged type II cells could be found. In addition, endothelial cells undergoing apoptosis were also noted in the lungs damaged by IAKI. Neutrophilic leukocyte infiltration was evident in alveolar septum with IAKI. Conclusions Both necrosis and apoptosis are involved in the lungs damaged by IAKI, but necrosis is more evident than apoptosis. Leukocyte infiltration is also involved in the lungs of RIRI animals.
Kidney / Ischemic acute kidney injury / Lung cell / Ultrastructure
[1] Li X, Hassoun HTb, Santora R, et al. Organ crosstalk : the role of the kidney
[J]. Current Opinion in Critical Care,2009,15(6):481-487.
[2] Klein CL, Hoke TS, Fang WF, et al. Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy
[J]. Kidney Int, 2008, 74(2):901-909.
[3] 申洪，沈英. 实用生物体视学技术
[M]. 广州中山大学出版社, 1991:156-158.
[4] Golab F, Kadkhodaee M, Zahmatkesh M, et al. Ischemic and nonischemic acute kidney injury cause hepatic damage
[J]. Kidney Int, 2009, 75(8):783-792.
[5] Santiago VR, Rzezinski AF, Nardelli LM, et al. Recruitment maneuver in experimental acute lung injury: the role of alveolar collapse and edema
[J]. Critical Care Medicine, 2010, 38(11):2207-2214.
[6] Hassoun HT, Lie ML, Grigoryev DN, et al. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis
[J]. Am J Physiol Renal Physiol, 2009, 297(1):125-137.
[7] Kroemer G, Galluzzi L, Vandenabeele P, et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
[J]. Cell death and Differentiation, 2009, 16(1):3-11.
[8] Kimdo J, Park ＳH, Sheen MR et al. Comparison of experimental lung injury from acute renal failure with injury due to sepsis
[J]. Respiration,2006,73(2):815-824.
[9] 张荣,张建龙,马琪,等.中性粒细胞在大鼠肾缺血再灌注造成肺损伤中的作用研究
[J].四川解剖学杂志,2008,16(3):4-7.
[10] Park SW, Chen SWC, Kim M, et al. Cytokines induce intestine and liver injury after renal ischemia or nephroctomy
[J]. Lab Invest, 2011, 91(1):63-84.
[11]Ricci Z, Ronco C. Pulmonary/renal interaction
[J]. Curr Opin Crit Care,2010, 16(1):13-18.
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