Objective　To investigate the clinical  effects  of  open  reduction, internal  fixation with pressure hollow screw  and  Kirschner  wire  on trans-scaphoid perilunate fracture-dislocation.　Methods　25 cases of trans-scaphoid  perilunate  fracture- dislocation were treated with  open  reduction, compression hollow screw  fixation of  the  scaphoid,  Kirschner  wire  fixation  of  intercarpal  joints, followed by the repair  of  the  joint capsule  and  special ligaments. The postoperative rehabilitation was performed.　Results　All  cases were followed  up about 7～24 months with  an average of 15 months. The wrist function was evaluated by Cooney scores, with the mean value of 82.  8 cases were excellent, 10 cases good, 5 cases fair and 2 case poor.  X-ray displayed that the fractures of scaphoid were healing   by first intention and  intercarpal joints  were  reduced. The gap between carpal bones was   normal.　Conclusions　It is helpful for the recovery of wrist function using open reduction, internal  fixation with pressure hollow screw and  Kirschner  wire, and the repair of the joint capsule and ligaments, during the treatment of trans-scaphoid  perilunate fracture dislocation.