Effects of secretoneurin on VCAM, MCP-1 and Ki67 expression in blood vessel smooth muscle cell
WU Jiao-Qiong, LUO Meng-Yang, SHU Wu, YANG Bao-Lin, LUO Hua, CA Wei-Jun
Chinese Journal of Clinical Anatomy ›› 2012, Vol. 30 ›› Issue (1) : 70-73.
Effects of secretoneurin on VCAM, MCP-1 and Ki67 expression in blood vessel smooth muscle cell
Objective To investigate the effect of secretoneurin on expression of VCAM, MCP-1 and Ki67 in blood vessel smooth muscle cells (VSMCs). Methods VSMCs culture from adult mouse thoracic aorta were randomly divided into normal control and SN experiment. The expression of VCAM, MCP-1 and Ki67 were detected by immunofluorescene. The result was viewed and recorded under confocal instrument，and the data were processed with EZ-C1 3.70 FreeViewer system．Results The expression of VCAM, MCP-1 and Ki67 in VSMCs treated with SN about 24h were significantlty increased compared to that of normal control (P＜0.05). Conclusions SN up-regulate the expression of VCAM, MCP-1，and promote the proliferation of vascular smooth muscle cells．
Secretoneurin / Vascular smooth muscle cells / Proliferation / Vascular cell adhesion molecule / Monocyte chemoattractant protein
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