The expression of Toll-like receptors 2 and 4 in the macrophages of hip synovium
CENG Zhan-Feng, DING Yue, HU Jie, HUANG Jian-Bin, QIN Chu-Jiang, WEN Chu-Ping, Barden Bertram
Chinese Journal of Clinical Anatomy ›› 2011, Vol. 29 ›› Issue (5) : 557-560.
The expression of Toll-like receptors 2 and 4 in the macrophages of hip synovium
Objective To explore the expression of TLR2 and TLR4 in the macrophages of hip synovium. Methods Hip synovium tissues were collected from 47 cases during hip surgery in our hospital from 2007 to 2010 and divided into three groups. 24 cases of femoral neck fracture were in group A, 18 cases of femoral head necrosis were in group B, and 5 cases of aseptic loosening were in group C. TLR2 and TLR4 were detected in synovial tissues of three groups by immunohistochemistry (sp), and the positive macrophages were observed, counted and analyzed statistically. Results The histoscore of TLR2 was 0.27±0.33/HP in Group A, 0.31±0.19/HP in Group B and 1.78±0.18/HP in the Group C. The histoscore of TLR4 was 0.69±0.18/HP in Group A, 0.71±0.31/HP in Group B and 2.00±0.39/HP in Group C. The expression of TLR2 and TLR4 in group C was significantly higher than that in group A and group B(P＜0.001). The expression of TLR4 was significantly higher than TLR2 among the three groups(P＜0.001). Conclusions TLR2 and TLR4 significantly increases in the macrophages of hip synovium around the prosthesis, which may be involved in macrophage-mediated process of aseptic joint loosening.
Toll-like receptors (TLRs) / Hip joint / synovium / Macrophages / Immunohistochemisty
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