Objective　To explore the clinical efficiency of the combined thoracic and abdominal multiple organ procurement.　Methods　We used U type thoracic incision combined with big cross abdominal incision, to set up in situ perfusion of thoracic and abdominal organs, while during the procedure of organs perfusion, we separated and en bloc harvested thoracic and abdominal organs.　Results　From 2003 to now, 8 cases underwent this surgical treatment, with the harvesting of 8 donor hearts, livers, pancreases, 8 pairs of lungs and 16 kidneys respectively. Warm ischemic time was about 2.0±1.2 min. No donor organs and vessels were damaged. Heart transplantation was performed in 6 cases, heart-lung combined transplantation in 2, double lung transplantation in 3, single lung transplantation in 5, liver-kidney combined transplantation in 2, pancreas-kidney combined transplantation in 3 and kidney transplantation in 11, respectively. The functions of all transplanted allograft recovered well.　Conclusions　Using combined thoracic and abdominal multiple organ procurement, the surgical process is rapidly and safely, which short the warm ischemic time and improve the activity and functions of donor organs.