Objective　To explore the relative safe nail insertion area, for manipulative reduction and the closed transcutaneous pining internal fixation microtrauma treatment of radius fracture, by measuring the distances from the wrist joint to radial styloid, tendon and blood-vessel at different wrist angles.　Methods　The wrist specimens of 20 adult forearm were fasted with external fixator. Under the palmar flexion positions of 0°, 20°, 40° and 60°, and the ulnar deviation of 0° and 30° respectively, the shortest distances between radius styloid vertex and carpi radialis longus muscle tendon, and that between radius styloid vertex and extensor pollicis brevis muscle tendon, between radius styloid vertex and the intersection point of carpi radialis longus muscle tendon, extensor carpi radialis brevis muscle tendon, extensor pollicis brevis muscle tendon and radial artery were measured respectively.　Results　Under the palmar flexion and ulnar deviation, the tendons surrounding radius styloid changed their position regularly. Safe nail insertion area amplified under the position of ulnar deviation about 30°, and palmar flexion 0° to 20°.　Conclusions　Taking radius styloid vertex as the surface landmark, with the wrist position of the ulnar deviation 30°, and palmar flexion about 0° to 20°, the treatment of radius fracture by Kirschner wire will be favorable for protecting the adjacent vessels and neves.