Objective  To improve the angiographic images of barium sulfate-latex injection technique and replace toxic lead oxide as the standard contrast medium. Methods  45 SD rats underwent angiography compared with different concentrations and types of latex, and the proportion of barium sulfate to latex, and adjusted radiographic parameters for the injection of barium sulfate. Results  The perfusate was prepared as follows: 10ml of latex was diluted in 20ml of water(20℃), with 27 grams of barium sulfate (used in clinical medicine) added. The average amount of barium sulfate mixture injected was 20-30ml/300g, which provided high quality angiograms. Conclusions  Modified Barium Sulfate-latex technique provides high-quality angiograms. Besides, barium sulfate does no harm to the health of researchers, which makes it a good method for the study of cutaneous artery and perforator flap.