Objective: To investigate the expression of CD44s in the nasal polyps and its role in pathogenesis of nasalpolyps. Methods: The polypus tissue from twenty cases of nasal polyps and inferior turbinate mucosa from fifteen healthy adults were collected. Immunohistochemical staining for CD44s and EGF protein, and HE staining for the nasal polyps and inferior turbinate mucosa were performed. Results:①The expression of CD44s protein in epithelium, vascular endothelial cells and inflammatory cells were 0.24±0.07，0.28±0.05，0.36±0.08 in nasal polyps and 0.11±0.02，0.13±0.03，0.22±0.04 in inferior turbinate mucosa respectively(P＜0.05). ②The number of Eos in nasal polyps was associated with CD44s protein in vascular endothelial cells (r=0.56,P＜0.05). ③ The expression of EGF protein in nasal polyps was higher than that in inferior turbinate (P＜0.05）. Conclusions: CD44s may play an important role in facilitating the transmigration of CD44s＋ inflammatory cell and the epithelialization after epithelial damage.