Research progress on ferroptosis-mediated intervertebral disc degeneration

doi:10.13418/j.issn.1001-165x.2025.1.16

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Chinese Journal of Clinical Anatomy ›› 2025, Vol. 43 ›› Issue (1) : 102-106. DOI: 10.13418/j.issn.1001-165x.2025.1.16

Research progress on ferroptosis-mediated intervertebral disc degeneration

Deng Zongyuan, Chen Chong, Liang Guoyan, Ye Yongyu, Yu Zhengran, Yu Tao, Wang Lutong, Liang Changxiang, Chang Yunbing*

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Abstract

Intervertebral disc degeneration (IVDD) is a common lesion in spinal surgery, which often leads to spinal degenerative diseases such as spinal stenosis and disc herniation. As age increases, its prevalence is on the rise. The pathogenesis of IVDD is complex and unclear, and there are currently no effective treatments. Ferroptosis is a novel form of cell death characterized by the accumulation of iron-dependent lipid peroxides and plays an important role in the development of many diseases. Recent studies have found that ferroptosis is closely related to the occurrence and development of IVDD, but its mechanism of action in IVDD has not yet been fully understood. This article reviewed the molecular mechanism of ferroptosis, the relationship between ferroptosis and IVDD, and its clinical application potential, aiming to provide new ideas for the prevention and treatment of IVDD.

Key words

Ferroptosis / / / Intervertebral disc degeneration / / / Oxidative stress / / / GPX4

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Deng Zongyuan, Chen Chong, Liang Guoyan, Ye Yongyu, Yu Zhengran, Yu Tao, Wang Lutong, Liang Changxiang, Chang Yunbing. Research progress on ferroptosis-mediated intervertebral disc degeneration[J]. Chinese Journal of Clinical Anatomy. 2025, 43(1): 102-106 https://doi.org/10.13418/j.issn.1001-165x.2025.1.16

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