Effect of pirfenidone on pulmonary interstitial fibrosis after COVID-19 in 2 cases

doi:10.13418/j.issn.1001-165x.2024.3.15

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Chinese Journal of Clinical Anatomy ›› 2024, Vol. 42 ›› Issue (3) : 331-335. DOI: 10.13418/j.issn.1001-165x.2024.3.15

Effect of pirfenidone on pulmonary interstitial fibrosis after COVID-19 in 2 cases

Wang Xia, Li Jiayi, Lu Huifen, Cui Haiyan*

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Abstract

Objective To observe and analyze the therapeutic effect of pirfenidone on pulmonary interstitial fibrosis secondary to COVID-19. Methods Clinical data of 2 patients with pulmonary interstitial fibrosis after severe COVID-19 were collected and followed up after discharged from our hospital, and the therapeutic effect of pirfenidone on anti-fibrosis secondary to COVID-19 was analyzed. Results After the two patients were treated with pirfenidone for 15 weeks and 9 weeks respectively, dynamic review of chest CT showed that the degree of pulmonary fibrosis in both patients was significantly reduced. Conclusions Pirfenidone may be effective in improving pulmonary fibrosis after COVID-19, but it still needs to be confirmed by longer duration of follow-up and clinical studies with more samples.

Key words

Novel coronavirus 2019; / / Coronavirus disease 2019; / / Pulmonary fibrosis; / / Pirfenidone

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Wang Xia, Li Jiayi, Lu Huifen, Cui Haiyan. Effect of pirfenidone on pulmonary interstitial fibrosis after COVID-19 in 2 cases[J]. Chinese Journal of Clinical Anatomy. 2024, 42(3): 331-335 https://doi.org/10.13418/j.issn.1001-165x.2024.3.15

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