两种神经功能重建术式对大鼠后肢运动功能恢复效果的比较

doi:10.13418/j.issn.1001-165x.2023.4.10

Abstract

Abstract: Objective To compare the clinical efficacy of "targeted muscle reinnervation (TMR)" and "targeted nerve function replacement (TNFR)" for neurological reconstruction in patients with amputation. Methods SD rats were randomly divided into a Sham group, a simple tibial nerve dissection (TNT) group, a TMR group and a TNFR group. The two operative efficacy were evaluated by footprint blotting, electromyography (EMG), and Sihler's intramuscular nerve staining. Results (1) Analysis of the footprint blotting results showed that the tibial nerve index in the TMR group (-13.79±5.289) was slightly smaller than that in the TNFR group (-12.30±4.06). (2) at the 8th week, compared with the TNT group, the amplitude of EMG on the affected side was greater in the TMR and TNFR groups (P<0.05). The amplitude of EMG on the affected side in the TNFR group was greater than that of the TMR group.(3) Sihler's intramuscular nerve staining results showed that the degree of nerve and muscle atrophy in the TNFR and TMR groups was less severe than that in the TNT group. The medial head of the gastrocnemius muscle in the TNFR group inherited the original function of the tibial nerve, and its nerve branches were denser compared with those in the TMR group. Conclusions Both TNFR and TMR can delay muscle atrophy and promote motor function reconstruction, and the long-term efficacy of TNFR is better than that of TMR.

Key words: Targeted muscle reinnervation, , , Targeted muscle nerve function reconstruction, , , Sihler's intramuscular nerve staining, , , Footprint analysis, , , Myoelectric signal

CLC Number:

R343

Jiang Mengnan , Zhang Ziju , Zhang Qianling, Su Huan, Gao Yifan , Lu Wei, Yang Lin . Comparison of the effect of two kinds of nerve functional reconstruction operation on the recovery of lower limb motor function in rats [J]. Chinese Journal of Clinical Anatomy, 2023, 41(4): 428-433.

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Comparison of the effect of two kinds of nerve functional reconstruction operation on the recovery of lower limb motor function in rats

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