Objective To explore the effects of resveratrol (RES) on brain tissue damage in rats with lacunar infarction (LI). Methods Sixty SD rats were divided into a sham operation group, a model group, a RES group and a combination group (RES+LY294002) averagely. LI models were prepared by sodium laurate method. The nerve function was evaluated by Zea-Longa's method. The cerebral infarction volume was observed by TTC. The levels of oxidative stress and inflammatory factors in brain tissues were detected by enzyme linked immunosorbent assay. The microvessel density was observed by Weidener method. The levels of phosphateidylinositol 3 kinase/serine-threonine kinase (PI3K/Akt) signaling pathways related proteins and vascular endothelial growth factor (VEGF) in brain tissues were detected by Western blotting. Results RES could reduce neurological scores, cerebral infarction volume and levels of MDA, TNF-α, IL-6 and IL-1β in LI rats (P<0.05), increase microvessel density, levels of SOD, CAT, GSH-PX and IL-10, and expressions of VEGF, p-PI3K and p-AKT proteins (P<0.05). Compared with the RES group, the above indexes in combination group showed an opposite trend (P<0.05). Conclusions RES can improve brain damage and angiogenesis in LI rats, and PI3K/Akt signaling pathways participate in this process.
Key words
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Lacunar infarction /
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Resveratrol /
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PI3K/Akt signaling pathway /
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Angiogenesis
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