Objective To explore the relationship between serum hepcidin and iron metabolism indicator in intracerebral hemorrhage and its application in assessment of early conditions and prognosis. Methods According to the selection, 92 patients were enrolled into an intracerebral hemorrhage (ICH) group and 92 healthy individuals into a control group. The levels of serum hepcidin（Hep）、 serum ferritin（SF）、interleukin-6（IL-6) were measured at 1, 3, 5, 7, 14 days after onset of ICH. ICH group were further divided into a mild ICH group，a moderate ICH group，and a severe ICH group according to their NIHSS score on the third day of admission. The modified Rankin Scale (mRS) score was evaluated at 3 months after ICH. According to the mRS scores, the patients was divided into a good outcome group (mRS≤2) and a poor outcome group (mRS>2). In the observation group, the volume coefficient of relative edema at the time of admission and 3 days after admission was calculated according to the CT data. The levels of Hep、 SF、IL-6 in the observation group and control group were compared at each time points. The relationship between the levels of Hep、 SF、IL-6 and the neurologic impairment and prognosis were analyzed. Results The levels of serum Hep、SF、IL-6 at each time points in the observation group were higher than those inthe control group, which were statistical differences in them (P<0.05, P<0.01). There were statistical differences in the levels of serum Hep、SF、IL-6 at each time points among the mild, moderate and severe ICH groups (P<0.01). There were statistical differences in the levels of serum Hep、SF、IL-6 at each time points among the good outcome group and the poor outcome group (P<0.01). The serum level of Hep in the observation group was positively correlated with those of SF, IL-6 and the relative volume coefficient of edema on the third day after admission (P<0.01). Conclusions The levels of serum hepcidin、SF、IL-6 are closely related to the occurrence, severity and prognosis of ICH , which can be used as a bioindicator of the severity and prognosis of ICH.
Key words
Intracerebral hemorrhage /
Serum hepcidin /
Serum ferritin /
Interleukin-6 /
Prognostic
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