Animal experimental study of new spinal external fixation surgery on paraspinal muscle injury

doi:10.13418/j.issn.1001-165x.2021.03.012

PDF(8364 KB)

Chinese Journal of Clinical Anatomy ›› 2021, Vol. 39 ›› Issue (3) : 311-318. DOI: 10.13418/j.issn.1001-165x.2021.03.012

Animal experimental study of new spinal external fixation surgery on paraspinal muscle injury

Li Shan¹， Peng Wen^1.2， Yan Yiguo¹， Wang Cheng¹ ，Song Xizheng¹，Li Xuelin¹， Ouyang Zhihua¹， Xue Jingbo¹，Wang Wenjun¹

Author information +

History +

Abstract

Objective　To verify the advantages of spinal external fixation surgery in reducing paraspinal muscle injury.　Methods　Ten goats were randomly divided into a spinal external fixation surgery group and an open internal fixation surgery group. The experimental animals were sacrificed at 3 months after operation. The lumbar vertebrae of the surgical segment were scanned by 3.0T MRI, and the paraspinal muscle tissue was completely dissected for quasi-static tensile test and pathological section. The effects of the two surgical methods on paraspinal muscle were analyzed.　Results　The goat animal model was successfully constructed. MRI showed that compared with the open internal fixation surgery group, there were only a small amount of muscle injury around the screw in the spinal external fixation surgery group. Quasi-static tensile mechanical tests, tissue section staining (HE staining, Masson staining) all suggested that there was less muscle injury in the spinal external fixation surgery group. There are statistical differences. Conclusions　The method of spinal external fixation through percutaneous nail implantation and external orthopedic fixation was verified to reduce the paraspinal muscle injury caused by postoperative internal fixation device compression and interference.

Key words

New spinal external fixator / 　Goat paraspinal muscle / 　Surgical injury / 　Animal experiment

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

Li Shan, Peng Wen, Yan Yiguo, Wang Cheng, Song Xizheng, Li Xuelin, Ouyang Zhihua, Xue Jingbo, Wang Wenjun. Animal experimental study of new spinal external fixation surgery on paraspinal muscle injury[J]. Chinese Journal of Clinical Anatomy. 2021, 39(3): 311-318 https://doi.org/10.13418/j.issn.1001-165x.2021.03.012

References

[1] 管礼安, 谭永超, 成业东. 胸腰椎骨折分型及开放性手术治疗的研究进展[J]. 颈腰痛杂志, 2016, 37(4): 336-339. DOI: 10.3969/j.issn.1005-7234.2016.04.004.
[2] Magerl FP. Stabilization of the lower thoracic and lumbar spine with external skeletal fixation[J]. Clin Orthop Relat Res, 1984, (189): 125-141. PMID: 6478690.
[3] Olerud S, Sjöström L, Karlström G, et al . Spontaneous effect of increased stability of the lower lumbar spine in cases of severe chronic back pain. The answer of an external transpeduncular fixation test[J]. Clin Orthop Relat Res, 1986, (203): 67-74. PMID: 2937596.
[4] 金正帅, 王道新, 范卫民, 等. 脊柱外固定复位器在胸腰椎骨折的应用[J]. 江苏医药, 2005, 31(2): 102-104, 76. DOI: 10.3969/j.issn.0253-3685.2005.02.008.
[5] 徐又佳, 郑祖根, 王以进, 等. 经椎弓根外固定器的设计和生物力学分析[J]. 中国脊柱脊髓杂志, 1994, 4(4): 152-156.
[6] 王文军, 宋西正, 王麓山, 等. 脊柱外固定器联合内窥镜技术治疗胸腰椎爆裂骨折[J]. 中国脊柱脊髓杂志, 2008, 18(10): 741-746. DOI: 10.3969/j.issn.1004-406X.2008.10.005.
[7] 宋西正, 康禹, 王程，等. 脊柱外固定动静结合治疗胸腰椎骨折的临床研究[J]. 中国中医骨伤科杂志, 2018, 26(12): 13-17.
[8] 刘洪, 王文军, 宋西正, 等. 新型脊柱外固定器的研制和生物力学测试[J]. 医学临床研究, 2006, 23(2): 148-150. DOI: 10.3969/j.issn.1671-7171.2006.02.002.
[9] 高万军. 微创椎弓根钉内固定在胸腰椎创伤性骨折治疗中的应用效果评价[J]. 当代医学, 2020, 26(2): 131-132. DOI: 10.3969/j.issn.1009-4393.2020.02.055.
[10] 宋西正, 汪向东, 王文军, 等. 脊柱外固定器的研制及其在胸腰椎骨折微创治疗中的临床应用[J]. 中国骨伤, 2008, 21(9): 698-699. DOI: 10.3969/j.issn.1003-0034.yyyy.nn.zzz.
[11]史亚民, 侯树勋, 韦兴, 等. 腰椎后路手术早期并发症的防治[J]. 中华骨科杂志, 2004, 24(9): 34-37. DOI: 10.3760/j.issn:0253-2352. 2004. 09. 008.
[12]刘国民, 孔宁, 韩宏志, 等. 鹿、羊和人腰椎生物学参数的比较及其意义[J]. 吉林大学学报(医学版), 2012, 38(6): 1096-1100, 1252.
[13]郑学天, 薛京浩, 崔成哲, 等. 眠乃宁(鹿眠宁)对141头次黑熊的麻醉试验[J]. 黑龙江畜牧兽医, 2004, (3): 44-45. DOI: 10.3969/j.issn.1004-7034.2004.03.028.
[14]甘胡勇, 彭广能, 胡霖, 等. 不同剂量鹿眠宝对山羊的麻醉效果观察[J]. 中国兽医杂志, 2010, 46(8): 30-32. DOI: 10.3969/j.issn.0529-6005.2010.08.011.
[15] 马建青, 吴占勇, 孔建军, 等. 山羊腰椎融合动物模型的围手术期管理[J]. 生物骨科材料与临床研究, 2018, 15(5): 5-7, 13. CNKI: SUN:SWGK.0.2018-05-002.
[16] 白万胜, 沙比提. 速眠新对卡拉库尔羊麻醉效果的研究[J]. 黑龙江畜牧兽医, 2012, (1): 120-121. CNKI: SUN:HLJX.0.2012-01-048.
[17] 王建林, 盛文亮, 孙祥贵, 等. 马头山羊躯干肌肉解剖研究[J]. 中国养羊, 1994, (1): 17-21.
[18] 洪汛宁, 王德杭, 王小宁, 等. 肌肉损伤磁共振成像的病理基础研究[J].南京医科大学学报, 2000, 20(5): 362-364. DOI: 10.3969/j.issn. 1007-4368.2000.05.012.
[19] 王欣, 李梅, 廖志钢, 等. 尸僵再形成的实验性研究[J]. 法医学杂志, 2001, 17(4): 202-204. DOI: 1004-5619(2001)04-0202-03.
[20] 王宝珍. 肌肉类软组织动态力学性能研究[D]. 合肥: 中国科学技术大学, 2010.
[21] 边蔷, 胡海威, 温建民, 等. 足部相关肌肉、肌腱组织材料弹性模量的测定[J]. 中国组织工程研究, 2015, 19(12): 1919-1923. CNKI: SUN:XDKF.0.2015-12-024.
[22] 唐兆升, 梁秀龄, 陈嵘, 等. 腓骨肌萎缩症腓肠神经病理的形态计量学[J]. 中山医科大学学报, 1998, 19(3): 24-27.
[23] 李洵桦, 田伟, 马耘田, 等. 近端型脊肌萎缩症骨骼肌病理及其形态定量分析的研究[J]. 中国神经精神疾病杂志, 2000, 26(2): 105-106. DOI: 10.3969/j.issn.1002-0152.2000.02.016.
[24] Bleiler C, Ponte Castañeda P, Röhrle O. A microstructurally-based, multi-scale, continuum-mechanical model for the passive behaviour of skeletal muscle tissue[J]. J Mech Behav Biomed Mater, 2019, 97: 171-186. DOI: 10.1016/j.jmbbm.2019.05.012.
[25] Morrow DA, Haut Donahue TL, Odegard GM, et al . Transversely isotropic tensile material properties of skeletal muscle tissue[J]. J Mech Behav Biomed Mater, 2010, 3(1): 124-129. DOI: 10.1016/j.jmbbm.2009.03.004.
[26] Silva M, Parente M, Brandão S, et al . Characterization of the passive and active material parameters of the pubovisceralis muscle using an inverse numerical method[J]. J Biomech, 2018, 71: 100-110. DOI: 10.1016/j.jbiomech.2018.01.033.
[27] Oh HS, Kim JS, Lee SH, et al . Comparison between the accuracy of percutaneous and open pedicle screw fixations in lumbosacral fusion[J]. Spine J, 2013, 13(12): 1751-1757. DOI: 10.1016/j.spinee. 2013. 03. 042.
[28] Hu ZJ, Fang XQ, Zhou ZJ, et al . Effect and possible mechanism of muscle-splitting approach on multifidus muscle injury and atrophy after posterior lumbar spine surgery[J]. J Bone Joint Surg Am, 2013, 95(24): e192(1-9). DOI: 10.2106/JBJS.L.01607.
[29] Hu Y, Leung HB, Lu WW, et al. Histologic and electrophysiological changes of the paraspinal muscle after spinal fusion: an experimental study[J]. Spine (Phila Pa 1976), 2008, 33(13): 1418-1422. DOI: 10.1097/BRS.0b013e3181753bea.
[30] Bresnahan L, Fessler RG, Natarajan RN. Evaluation of change in muscle activity as a result of posterior lumbar spine surgery using a dynamic modeling system[J]. Spine (Phila Pa 1976), 2010, 35(16): E761-E767. DOI: 10.1097/BRS.0b013e3181e45a6e.
[31] Mori E, Okada S, Ueta T, et al. Spinous process-splitting open pedicle screw fusion provides favorable results in patients with low back discomfort and pain compared to conventional open pedicle screw fixation over 1 year after surgery[J]. Eur Spine J, 2012, 21(4): 745-753. DOI: 10.1007/s00586-011-2146-2.