Objective　To investigate the clinical effect of the treatment on the diseases of anterior medial and inferior wall of maxillary sinus by endoscopic prelacimal recess approach.　Methods　The clinical data of 67 patients with various maxillary sinus lesions treated by crypt in the treatment of various maxillary sinus lesions were analyzed retrospectively in the three hospitals from January 2008 to January 2018.　Results　Twenty cases of lower wall cysts in the upper jaw sinus, 6 cases of lower wall polyps in the upper jaw sinus, 2 cases of internal epithelial papilloma, 23 cases of fungal globular sinusitis, 13 cases of allergic reactive fungal sinusitis, 1 case of chronic aggressive fungal sinusitis. All patients were followed-up regularly after surgery for more than half a year without relapse.　Conclusions　The prelacrimal recess approach under nasal endoscope can fully expose the maxillary sinus cavity and completely remove the lesions in the maxillary sinus. The operation is convenient and can effectively treat various benign lesions of the maxillary sinus, such as obvious prelacrimal recess and alveolar recess, it can be used as the first choice of surgical approach for maxillary sinus anterior medial inferior wall lesions.