Objective　To compare the clinical application of percutaneous endoscopic BEIS and TESSY technology in L5~S1 disc herniation and to evaluate its clinical value.　Methods　Sixty patients with L5-S1 disc herniation treated by Foshan Sixth People's Hospital from January 2018 to June 2019 were collected and were randomly divided into the following two groups: a BEIS technology group (observation group) and a TESSY technology group (control group), each with 30 cases, and were followed up for 6~18 months. The gender, age, time of operation, number of X-ray machines in C-arm during operation, postoperative complications and surgical results were compared between the two groups to evaluate the therapeutic effect and clinical value of different techniques.　Results　Sixty patients were followed up for 12 months on average, there were no statistical difference in gender, age of the two groups  (P>0.05). Compared with the TESSY group, the BEIS group had shorter operation time and fewer C-arm fluoroscopy, with statistically significant difference (P<0.05). During the 6 months after surgery follow-up and the last time follow-up, there were no statistical difference in the VAS and ODI scores of the two groups (P>0.05) . There was one case of postoperative recurrence in each of the two groups, both recovered well after the second open operation, and there was no statistical difference in the incidence of postoperative complications (P>0.05).　Conclusions　Percutaneous endoscopic BEIS and TESSY are safe, effective and minimally invasive treatments for L5~S1 disc herniation and BEIS is easier to master. BEIS technology have certain advantages in the operation time and intraoperative perspective on treatment of the L5~S1 disc herniation.