Effect of low-dose ultrashort wave on functional recovery and expression of serum iNOS, TNF-α, VEGF, and BDNF in patients with spinal cord injury

doi:10.13418/j.issn.1001-165x.2020.05.019

Chinese Journal of Clinical Anatomy ›› 2020, Vol. 38 ›› Issue (5) : 588-592. DOI: 10.13418/j.issn.1001-165x.2020.05.019

LIANG Ai-ping， LI Wen-hui

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Abstract

Objective　To investigate the effect of low-dose ultrashort wave on functional recovery and serum inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) expression.　Methods　Sixty patients with spinal cord injury were enrolled and randomly divided into a treatment group and a control group, with 30 cases in each group. The control group was given basic rehabilitation treatment, and the treatment group was treated with small dose ultrashort wave therapy for a total of 3 courses of treatment. Efficacy was assessed and factors affecting spinal function recovery were analyzed.　Results　The total effective rate of the treatment group was higher than that of the control group (P<0.05). After rehabilitation treatment, the motor function and sensory function scores of the ASIA scale in the treatment group were higher than those in the control group (P<0.05). The levels of serum VEGF and BDNF in the treatment group were higher than those in the control group (P<0.05). The expression levels of iNOS and TNF-α in the treatment group were lower than those in the control group (P<0.05). Low dose ultrashort wave therapy was a protective factor for prognosis of patients with spinal cord injury (P<0.05).　Conclusions　Low-dose ultrashort wave adjuvant therapy can significantly promote the recovery of spinal cord function in patients, which may be related to down-regulation of serum iNOS, TNF-α expression and up-regulation of VEGF and BDNF expression.

Key words

/ Ultrashort wave；　Spinal cord injury；　Spinal cord function；　iNOS；　TNF-α

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LIANG Ai-ping, LI Wen-hui. Effect of low-dose ultrashort wave on functional recovery and expression of serum iNOS, TNF-α, VEGF, and BDNF in patients with spinal cord injury[J]. Chinese Journal of Clinical Anatomy. 2020, 38(5): 588-592 https://doi.org/10.13418/j.issn.1001-165x.2020.05.019

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