Objective To explore the effects of Runzao Zhiyang capsule (RZC) on psoriatic lesions from the perspective of regulation on gut microbiota and immune inflammation. Methods Effect of RZC on rat model with psoriatic lesions was studied. Levels of inflammatory cytokines (IL-6、TNF-α、IL-17 and IL-10) in the plasma were detected. The number of major bacterial colonies in feces was analyzed. Results After treatment with RZC for two weeks, symptoms of psoriatic lesions in rats were significantly improved. The levels of IL-17, IL-6, and TNF-α in the plasma were down-regulated by RZC, but the IL-10 level was up-regulated by RZC, respectively, which indicating the amelioration of inflammatory response. RZC also reduced the amounts of escherichia and enterococcus, and increased the number of lactobacillus and bifidobacteria in the gut. Conclusions RZC treats psoriatic lesions, which maybe related to modulating gut microbial structure, and ameliorating immune inflammatory response of the host.
Key words
Runzao Zhiyang capsule; /
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Psoriatic lesion; /
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Gut microbiota; /
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Inflammatory response
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