Objective To explore the feasibility of a simple rabbit model of right coronary artery ischemia-reperfusion injury by threading ligation. Methods 20 New Zealand white rabbits, male or female, weighing (2.5±0.3) kg, were divided into two groups: an ischemia-reperfusion group (14 rabbits) and a sham operation group (6 rabbits). Threading without ligation were treated in the sham operation group, a model of rabbit right coronary artery ischemia-reperfusion injury was constructed after loosening the thread of 30 min preset suture ligation. The electrocardiogram was recorded, the changes of creatine kinase isoenzyme (CK-MB) before and after ligation, and the condition of postoperative hose insertion into the right crest were compared. Results The ST segment significantly elevated, the hose inserted into the right coronary artery was difficult to drag out and the creatine kinase isoenzyme increased in 8 cases. The success rate of the model was 57% (8/14). There were no significant changes among the above indicators in the sham operation group. Conclusions This study explores the model of right coronary artery ischemia-reperfusion-reperfusion injury, and the modeling is basically successful.
Key words
Ischemia-reperfusion injury /
Right coronary artery /
Animal model
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