Study of the clinical effects of two improved autogenous bone fusion methods
ZHONG Zhi-hong, ZHOU Wei, YU Hao-tao, ZHANG Liang, ZHANG Zhi, ZHANG Pin, LI Jian
Chinese Journal of Clinical Anatomy ›› 2017, Vol. 35 ›› Issue (6) : 671-675.
Study of the clinical effects of two improved autogenous bone fusion methods
Objective To retrospectively study the clinical effect of two improved autologous bone lumber interbody fusion methods (autogenous bone interbody fusion cage(ABIF) and autogenous morselized bone graft impaction(AMBI)) compared with the PEEK cage fusion. Methods The clinical data of 110 cases of patients who took the lumber fusion surgery from 2010 to 2016 were collected. All the cases were divided into three groups by the fusion method: AMBI:36 cases, ABIF:35 cases, PEEK:39 cases. The VAS score, ODI score at the time point of pre-operation, 6 months post-operation and 12 months post-operation were evaluated, the loss of intervertebral space height on X-ray and the relative fusion rate on CT scanning at the time point of 24 h post-operation, 6 months post-operation and 12 months post-operation was evaluated. The general information of three groups had no statistical significance, indicating good comparability of the three groups. Result All three groups had no serious complications. The loss of intervertebral space height 6m and 12 m post-operation of each group: AMBI:(6.1±2.5、6.5±3.8)%, ABIF:(5.6±2.9、5.8±3.7)%；PEEK:(5.4±3.3、5.9±4.1)%,the relative fusion rate 6 months and 12 months post-operation of each group: AMBI:(27.5±10.5、26.5±9.1)%, ABIF:(31.2±8.7、28.1±8.7)%, PEEK:(28.4±7.1、29.3±8.2)%。Statistical results showed VAS score, ODI score, loss of intervertebral space height and the relative fusion rate 6m and 12m post-operation of each group have no statistical significance (P＞0.05). Conclusion All three groups have the same clinical effect and fusion rate, the result indicate a good promise of clinical application of AMBI and ABIF.
Autogenous bone interbody fusion; Autogenous morselized bone graft impaction / Interbody fusion
[1] Lawrence JP, Waked W, Gillon TJ, et al. rhBMP-2(ACS and CRM formulations) overcomes pseudarthrosis in a New Zealand white rabbit posterolateral fusion model[J]. Spine, 2007, 32(11):1206-1213.
[2] Park JJ, Hershman SH, Kim YH. Updates in the use of bone grafts in the lumbar spine[J].Bull Hosp Jt Dis, 2013, 71(1):39-48.
[3] Baker JF, Errico TJ, Kim Y, et al. Degenerative spondylolistheis: contemporary review of the role of interbody fusion[J].Eur J Orthop Surg Traumatol, 2017, 27(2):169-180.
[4] Assem Y, Mobbs RJ, Pelletier MH, et al. Radiological and clinical outcomes of novel Ti/PEEK combined spinal fusion cages:a systematic review and preclinical evaluation[J]. Eur Spine J, 2017, 26(3):593-605.
[5] Chong E, Pelletier MH, Mobbs RJ, et al. The design evoultion of interbody cages in anterior cervical discectomy and fusion: a systematic review[J].BMC Musculoskelet Disord, 2015, 16(1):99-110.
[6] Boden SD. Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute[J]. Spine, 2002, 27(16 Suppl 1):S26-S31.
[7] 王小刚, 罗建平, 杨彬, 等. 新型后路同种异体骨解剖形腰椎融合器治疗腰椎间盘突出症的疗效分析[J]. 中国临床解剖学杂志, 2016, 34(4):450-453.
[8] Salamanna F, Sartori M, Brodano GB, et al. Mesenchymal stem cells for the treatment of spinal arthrodesis: from preclinical research to clinical scenario[J]. Stem cell Int, 2017, 2017(407):1-27.
[9] Madan S, Boeree NR. Outcome of posterior lumbar interbody fusion versus posterolateral fusion for spondylolytic spondylolisthesis[J].Spine, 2002, 27(14): 1536-1542.
[10]Buser Z, Brodke DS, Youssef JA, et al. Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review[J]. J Neurosurg Spine, 2016, 25(4):509-516.
[11]Tuchman A, Brodke DS, Youssef JA, et al. Iliac crest bone graft versus local autograft or allograft for lumbar spinal fusion: a systematic review[J]. Global Spine J, 2016, 6(6):592-606.
[12]Wang L, Huang H, Zhang Z, et al. Biomechanical evaluation of a novel autogenous bone interbody fusion cage for posterior lumbar interbody fusion in a cadaveric model[J]. Spine, 2014, 39(11):E684–E692.
[13]钟志宏, 李健, 张平, 等. Cage椎弓根内固定联合自体颗粒骨打压植骨的即时生物力学稳定性[J]. 中国组织工程研究与临床康复, 2011, 15(26): 4825-4828.
[14]李健, 石林毅, 黄景祥, 等. 自体骨cage 在后路腰椎间融合手术中的临床应用观察[J]. 实用医学杂志, 2013, 29(16): 2701-2704.
[15]李健, 张震山, 赵洪普, 等. 自体颗粒骨打压植骨腰椎椎间融合术治疗下腰椎退变性不稳的疗效[J]. 广州医学院学报, 2010, 38(5):24-27.
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