Observation of the effect of induced membrane in the treatment of infective bone defects
YIN Qu-dong， GU San-jun， SUN Zheng-zhong， WU Yong-wei, RUI Yong-jun, HU Hui-dong
Chinese Journal of Clinical Anatomy ›› 2017, Vol. 35 ›› Issue (4) : 459-462.
Observation of the effect of induced membrane in the treatment of infective bone defects
Objective To investigate the effect of induced membrane in the treatment of infective bone defects. Methods From January 2008 to December 2015, 38 patients with infective bone defects were treated with vancomycin bone cement packing and staged bone grafting. They were divided into encapsulation group with induced membrane(group A, 24 cases) and no-encapsulation group(group B, 14 cases).Bone healing, recurrence of infection and intervention of resurgery were recorded, grade of bone healing and adjacent joint functional recovery were evaluated according to Paley method, respectively. Results All patients were followed up for 12 to 51 months, with an average of 19.6 months. In group A, all healed by first intention, the clinical healing time was 3.0～7.0 months, with an average of 5.2 months; in group B, 1 case had bone nonunion, and the clinical healing time was 3.0～15.0 months, with an average of 6.64 months. 1 case with recurrence of infection was noted in group A whereas 3 cases were noted in group B. 3 cases required intervention of resurgery in group B whereas no case was noted in group A. The clinical healing time and intervention rate of resurgery were statistically different (P<0.05); a trend of higher recurrence rate in group B than in group A was noted although there was no significant difference between the two groups (P>0.05). At the last follow-up, there was no significant difference between the two groups in the grade of bone defect healing and the functional recovery of the adjacent joint (P>0.05). Conclusion The integrity of the induced membrane is related to bone healing, and the induced membrane formed after packing of antibiotic bone cement has a protective effect on the recurrence of infection.
/ Induced membrane technique； / Induced membrance； / Bone defect； / Osteomyelitis
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