The researchon rat nerve growth factor in the treatment of tibial fracture nonunion
LIU Yu-tao，HUANG Chao-tong，CHEN Long-fu， HU Wang-shan，LI Yu-hui，LIN Fang-zhu
Chinese Journal of Clinical Anatomy ›› 2016, Vol. 34 ›› Issue (3) : 326-330.
The researchon rat nerve growth factor in the treatment of tibial fracture nonunion
Objective To study therapeutic effect of rat nerve growth factor (NGF) on rabbit tibial nonunion treatment and provide a reference for its clinical application. Method 40 healthy adult male New Zealand white rabbits underwent establishment of transverse fracture nonunion model about 3~5 cm under the right tibial tuberosity，and were divided randomly and equally into the experimental group and the control group：the experimental group received injection of NGF at the fracture site once a week for 12 weeks; the control group received injection of normal saline at the fracture site once a week for 12 weeks. Both groups received X-ray and histological observation in the same time to observe callus growth and bone healing during the experiment. Results In the experimental group, callus appeared in (2.0±0.5) weeks, the fracture line became blurred in (8.2±1.2) weeks, and bone healed in (12±1.7) weeks; in the control group, callus appeared in more than 8 weeks, no fracture line became blurred or bone healed. Fracture healing in the experimental group was much better than that in the control group. According to the statistics processing,the difference had statistical significance(P<0.05). Conclusion NGF has a strong promotion of bone nonunion callus growth and healing, and its broad application prospect in the clinical treatment of nonunion might be viewed.
Nerve growth factor / Rabbit / Fracture / Nonunion / Research
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