Study on childhood generalized tonic seizures using regional homogeneity analysis
GUO Hong-hua, HUANG Wen-hua, HUANG Li-jin，LI Yong-xin, HUANG Wei-jia, TAN Zhen
Chinese Journal of Clinical Anatomy ›› 2016, Vol. 34 ›› Issue (3) : 278-284.
Study on childhood generalized tonic seizures using regional homogeneity analysis
Objective Regional homogeneity(ReHo) method of resting state functional MRI was applied to study abnormal brain activity of childhood generalized tonic seizures,and detect pathophysiological mechanisms of it. Methods Resting state fMRI scanning were performed to 8 patients with childhood generalized tonic seizures and 30 healthy children.The MRI data were compared and analyzed by using ReHo analysis method, the ReHo value were calculated between two groups and the correlation were studied between the ReHo value and seizure duration. Result Compared with control group, the brain regions of increased ReHo value in experimental group are located in deep brain nuclei(cingulate gyrus，precuneus，thalamus，et al.)，motor related brain region, inferior frontal gyrus, occipital lobe，temporal gyrus，cerebellum;the brain regions of decreased ReHo value in experimental group are bilateral middle frontal gyrus, right middle temporal gyrus, left superior temporal gyrus, bilateral posterior central gyrus, lingual gyrus.The positive correlation between ReHo and epilepsy duration was found in the following brain regions: left precuneus, left superior parietal lobe, right precentral lobule, right postcentral lobule.At the same time negative correlation was found in the right precuneus, right angular gyrus, paracentral lobule. Conclusion ReHo analytical method can effectively reflect abnormal neurological functional change of the epilepsy patients, and help to investigate and explain the pathophysiology of idiopathic generalized tonic seizures.
Functional MRI / Resting-state / Regional homogeneity / Generalized tonic seizures
[1] Zang Y, Jiang T, Lu Y, et al. Regional homogeneity approach to fMRI data analysis[J]. Neuroimage,2004,22(1):394-400.
[2] 乔鹏飞，牛广明，韩晓东. 利用脑局部一致性算法对原发性复杂部分性发作癫痫的磁共振研究[J]. 中国CT和MRI杂志, 2011,09(5):32-35.
[3] 夏丽坤，江桂华，汪天悦，等. 基于局部一致性方法的广泛性焦虑障碍患者静息态功能磁共振成像[J]. 中国医学物理学杂志, 2016,33(1):30-33.
[4] Sheng K, Fang W, Su M, et al. Altered spontaneous brain activity in patients with Parkinson's disease accompanied by depressive symptoms, as revealed by regional homogeneity and functional connectivity in the prefrontal-limbic system[J]. PLoS One,2014,9(1):e84705.
[5] Uhlhaas P J, Singer W. Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology[J]. Neuron,2006,52(1):155-168.
[6] Haneef Z, Lenartowicz A, Yeh H J, et al. Effect of lateralized temporal lobe epilepsy on the default mode network[J]. Epilepsy Behav,2012,25(3):350-357.
[7] Buckner R L, Andrews-Hanna J R, Schacter D L. The brain's default network: anatomy, function, and relevance to disease[J]. Ann N Y Acad Sci,2008,1124:1-38.
[8] Norden A D, Blumenfeld H. The role of subcortical structures in human epilepsy[J]. Epilepsy Behav,2002,3(3):219-231.
[9] Gotman J, Grova C, Bagshaw A, et al. Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain[J]. Proc Natl Acad Sci U S A,2005,102(42):15236-15240.
[10]Buckner R L. The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging[J]. Neuron,2013,80(3):807-815.
[11] Zeng H, Ramos C G, Nair V A, et al. Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study[J]. Epilepsy Res,2015,116:79-85.
[12] Barba C, Barbati G, Di Giuda D, et al. Diagnostic yield and predictive value of provoked ictal SPECT in drug-resistant epilepsies[J]. J Neurol,2012,259(8):1613-1622.
[13]Gainotti G. Unconscious processing of emotions and the right hemisphere[J]. Neuropsychologia,2012,50(2):205-218.
[14] Pittau F, Grova C, Moeller F, et al. Patterns of altered functional connectivity in mesial temporal lobe epilepsy[J]. Epilepsia,2012,53(6):1013-1023.
/
| 〈 |
|
〉 |
