The research of tea polyphenols for liver failure due to chronic alcoholic liver damage
TANG Yin-juan，WANG Jian-jun,WANG Xiang-hai,PAN Meng-jie,CHEN Zhuo,XIAO Ling-long, LIU Jia-hua, CAI Wei-jun
Chinese Journal of Clinical Anatomy ›› 2016, Vol. 34 ›› Issue (2) : 198-201.
The research of tea polyphenols for liver failure due to chronic alcoholic liver damage
Objective To investigate the preventive effect of tea polyphenols from liver injury in chronic alcoholism, and explore its possible molecular mechanisms. Methods 40 male kunming mice were divided into a control group, an alcohol group, a low dose group and a high dose group randomly. The mice model of alcoholic liver injury was duplicated by gavage and was given Alcohol and tea polyphenol respectively, using pure water as the control group. Then the mice′s AST, ALT, SOD, MDA, ROS, GSH-px,Bcl-2 and Bax of blood serum and liver tissue in each group weredetermined. Result The treatment medicine indicated that both the high or low doses of tea polyphenols could reduce the model of mice′s liver damage. Conclusion The tea polyphenols could alleviate liver injury through inhibiting the preoxidation and eliminating free radicals.
Tea polyphenols / Alcohol poisoning / Liver / Bcl- 2 / Bax
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