Changes of the periosteal reaction of diabetic rat and the protection of genistein
Chinese Journal of Clinical Anatomy ›› 2016, Vol. 34 ›› Issue (1) : 73-77.
Changes of the periosteal reaction of diabetic rat and the protection of genistein
Objective To study the changes of the periosteal reaction of the diabetic rat and the protection of genistein. Methods The diabetic model (STZ) of rat was established and randomly divided into a normal group and adiabetic group, with 10 rats in each group； GenLow group； GenHigh group. 20 rats each group. The change of collagen fiber depositing was observed by Van Gieson collagen fiber staining method and the microvascular density was measured by ink infusion method. Results The thickness of periosteum wasreduced in the 10-week diabetic group than those in the control group(P<0.01), the microvascular density and permeability were enlarged. Thickness of periosteum was reduced by GenLow and by GenHigh after 10 weeks of treatment (P<0.01). Conclusions With periosteal reaction include periosteal edema, proliferation and regression in the diabetic. Gen could protect the periosteum in the diabetes rats.
Diabetes / Periosteum / Periosteal reaction / Genistein / Osteogenitor cell / Collagen / Microvesses / Infusion with ink
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