Protection and mechanism of dexmedetomidine preconditioning against neuronal injury related to oxygen-glucose deprivation
LI Gong-Yang, ZHANG Jian-Xing, WANG Xing, XU Wei, ZHOU Guo-Bin
Chinese Journal of Clinical Anatomy ›› 2014, Vol. 32 ›› Issue (4) : 455-457.
Protection and mechanism of dexmedetomidine preconditioning against neuronal injury related to oxygen-glucose deprivation
Objective To study the protection and mechanism of dexmedetomidine preconditioning against neuronal injury related to oxygen–glucose deprivation(OGD). Methods Cortical neurons from the embryonic day 16~18 rats were cultured. With mimicking a cerebral ischemia in vitro, OGD was performed in the pretreated cells. Neuron injury was assessed by MTT. Protein expression of p-p38 was examined by Western blot. Results Dexmedetomidine preconditioning protected the dose-dependent cortical neurons from OGD injury. Conclusions Dexmedetomidine preconditioning protects the cortical neuron from OGD injury; inhibition of p38MAPK pathway maybe one of the mechanisms responsible for this effect.
Dexmedetomidine / Oxygen-glucose deprivation / Cortical neurons / Rats
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